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´ë»ç¼ºÁúȯ (´ç´¢º´, ºñ¸¸, Áö¹æ°£ (NFALD-ºñ¾ËÄݼº Áö¹æ°£¿°, NASH-ºñ¾ËÄݼº Áö¹æ°£¿°), dyslipidemia (ÀÌ»óÁöÇ÷Áõ), µ¿¸Æ°æÈÁõ, ½ÉÇ÷°ü Àå¾Ö)¿¡ ´ëÇÑ ¿¹¹æ, Ä¡·áÁ¦¿¡ ´ëÇÑ ¾àÈ¿ °Ë»öÀ» in vitro ¹× in vivo modelÀ» ÀÌ¿ëÇÏ¿© ¼öÇà. |
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´ç´¢º´ ¹× ºñ¸¸ |
¡Ý ½ÄÀÌ¿¡ ÀÇÇØ À¯¹ß½ÃŲ ´ç´¢º´ ¸ðµ¨ µ¿¹° ȤÀº ¼±ÃµÀû ¼ÒÀÎÀ» °®´Â ½ÇÇ赿¹° (db/db, ob/ob, ZDFµî) ÀÌ¿ë
¡Ý Gold-standard methods (euglycemic hyperinsulinemic clamp, hyperglycemic clamp)
¡Ý Á¦ 2Çü ´ç´¢º´¿¡ ´ëÇÑ Ä¡·áÁ¦ Èĺ¸¹°ÁúÀÇ ¾àÈ¿ °Ë»ö
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ÀÌ»óÁöÇ÷Áõ ¹× µ¿¸Æ°æÈÁõ |
¡Ý ÀÌ ºÐ¾ßÀÇ ÃÖ°í Àü¹®°¡µé·Î ±¸¼º
¡Ý ´Ù¾çÇÑ µ¿¹° ¸ðµ¨ÀÇ È°¿ë
¡Ý Gold-standard methods ¹× ÀÚü °³¹ß ±â¼ú (ox-LDL propriety ±â¼ú)
¡Ý °í°´ÀÇ ¿ä±¸¿¡ ´ëÀÀÇÑ ¸ÂÃãÇü ½ÇÇè ¼³°è
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µ¿¹° ¸ðµ¨ |
¡Ý ½ÄÀÌ À¯¹ß µ¿¹° ¸ðµ¨ |
¢¡ Àν¶¸° ÀúÇ× ¹× ÀÌ»óÁöÇ÷Áõ ÇܽºÅÍ ¸ðµ¨ = Àν¶¸° ÀúÇ×¼º ¹× ´ç´¢º´, ÀÌ»óÁöÇ÷Áõ, hepatic steatosis (Áö¹æ°£)
¢¡ °íÁö¹æ ½ÄÀÌ¿¡ ÀÇÇÑ °íÄÝ·¹½ºÅ×·Ñ Ç÷Áõ ¸ðµ¨ = »ç¶÷°ú À¯»çÇÑ ÁöÁú´Ü¹éÁú ´ë»ç ÀÌ»ó(°í LDL-c ³óµµ¿Í ³ôÀº CEFP Ȱ¼º)
¢¡ CETP-apoB100 À¯ÀüÀÚº¯Çü »ýÁã¿¡ °íÁö¹æ ½ÄÀ̸¦ Åõ¿© = µ¿¸Æ°æÈÁõ À¯¹ß
¢¡ ½ÄÀÌ¿¡ ÀÇÇÑ ºñ¸¸ rat = °íÇ÷´çÁõ, Àν¶¸° ºÐºñ ÀúÇØ, Àν¶¸° ÀúÇ×¼º
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¡Ý À¯ÀüÀÚ º¯Çü µ¿¹° ¸ðµ¨ |
¢¡ Apo E mouse, ApoB 100 mouse, CETP mouse, ob/ob mouse, db/db mouse, Zucker Diabetic Fatty rat µî
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½ÇÇèÁöÇ¥µé |
¡Ý In vivo screening |
¢¡ Gold standard method
1. macrophage-to-feces reverse transport
2. HDL/LDL-chloesterol kinetics
3. Whole body FFA turnover
4. Euglycemic hyperinsulinemic clamp
5. Hyperglyemic clamp
¢¡ In-house innovative and validated technique
1.ox-LDL-reverse cholesterol transport
2. intestinal triglycerides/cholesterol absorption
3. in vivo individual tissue FFA storage rate
4. VLDL-TG production test
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¡Ý Ex vivo screening |
¢¡ muscles/adipocytes ex vivo FFA oxydation
¢¡ muscles/adipocytes ex vivo glucose uptake
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¡Ý Biochemistry /Biomarkers : ÁöÁú´ë»ç¿¡ °ü·ÃÇÑ ¹°Áúµé¿¡ ´ëÇÑ ´Ù¾çÇÑ ÁöÇ¥°Ë»çg |
¢¡ Ç¥ÁØ ÁöÇ¥µé
1. Free fatty acids, triglycerides, glycerol
2. HDL-C, LDL-c, VLDL-C, total cholesterol, FPLC profiles
3. Creatine, CRP, ALP, AST, ALT, Creatine Kinase, Phosphate, Urea, Insulin, Glucose, Grehlin,
Glucagon, Glucoincretins, Albumin, HbA1c
¢¡ ¿°Áõ ÁöÇ¥µé : TNF-a, IL-6, MCP-1
¢¡ Adipokine Ç÷Áß ÁöÇ¥µé : Adiponectin, leptin
¢¡ Á¶Á÷ ºÐ¼® : Triglycerides, Cytokines, Western blotµî
¢¡ ±âŸ : lipid tolerance test, feces analsyses, FPLC lipoprotein profiling, Histopathology,
Cardiometabolic parameters
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