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Immuno Oncology -Shanghai Model Organisms Center, Inc. |
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Repository of Research-Ready GEM models |
We offer 1000+ Research-Ready mouse models to jump start your mouse experiments |
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Tool Mice |
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Including: Cre recombinase, reporter gene, and Cas9-related mice |
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Disease Mice |
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Mouse models of human diseases for studying the role of genes in the inheritance, pathogenesis and progression of diseases. |
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Fluorescent Reporter Mice |
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Mouse models carrying knock-in or transgenic fluorescent reporter genes for gene expression profiling and visual analysis, protein subcellular localization, and genetic lineage tracing. |
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Humanized Mice (Immuno-Oncology) |
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Humanized mice of drug target genes, such as humanized mice of immune checkpoint genes, for drug screening and drug efficacy evaluation, helping accelerate the development of drugs. |
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Tumor cell lines |
SMOC reserves over 100 commonly used tumor cell lines, mostly derived from the ATCC and the Chinese Academy of Sciences Collection Committee cell bank. |
These cell lines can be used to offer technical services such as cell line knock-in/knock-out, cell proliferation/apoptosis, and cell migration/invasion. |
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Fluorescent-Labeled Cells |
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Primary Cells |
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GEM Models |
Customized service (ÁÖ¹®Á¦ÀÛ), CRISPR - Cas9 Technology |
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Gene Knockout |
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Conventional (constitutive) gene knockout, Conditional gene knockout, KO first |
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Gene Knock-in |
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Conventional gene knock-in, Point mutation, Conditional point mutation, Humanization |
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Gene Overexpression |
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Targeted conditional overexpression, Random Transgenes |
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Applications of Animal Models |
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Study of gene functions |
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To study the in vivo function of a gene or its encoded protein and identify its role within cellular processes. |
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Research on human diseases |
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To mimic human diseases for the research on pathogenesis, development processes, gene-regulation, therapeutic treatments, etc. Cancer, Hemophilia, Dysgenesis, Inflammation, Aging and Longevity, Osteoporosis, Pleomorphic Adenoma |
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Drug screening |
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To allow focused and high-throughput in vivo drug screening for more valuable pre-clinical research and accelerate drug development. |
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Gene tracking |
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To visualize the in vivo expression of genes or proteins to uncover cell fate and genetic lineage. |
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