 |
|
|
|
|
 |
 |
|
| |
|
|
|
| |
|
Immuno Oncology -Shanghai Model Organisms Center, Inc. |
 |
| |
Repository of Research-Ready GEM models |
| We offer 1000+ Research-Ready mouse models to jump start your mouse experiments |
 |
Tool Mice |
|
Including: Cre recombinase, reporter gene, and Cas9-related mice |
|
Disease Mice |
|
Mouse models of human diseases for studying the role of genes in the inheritance, pathogenesis and progression of diseases. |
|
Fluorescent Reporter Mice |
|
Mouse models carrying knock-in or transgenic fluorescent reporter genes for gene expression profiling and visual analysis, protein subcellular localization, and genetic lineage tracing. |
|
Humanized Mice (Immuno-Oncology) |
|
Humanized mice of drug target genes, such as humanized mice of immune checkpoint genes, for drug screening and drug efficacy evaluation, helping accelerate the development of drugs. |
|
 |
|
| |
|
Tumor cell lines |
| SMOC reserves over 100 commonly used tumor cell lines, mostly derived from the ATCC and the Chinese Academy of Sciences Collection Committee cell bank. |
| These cell lines can be used to offer technical services such as cell line knock-in/knock-out, cell proliferation/apoptosis, and cell migration/invasion. |
|
Fluorescent-Labeled Cells |
|
Primary Cells |
|
|
| |
| |
|
GEM Models |
| Customized service (주문제작), CRISPR - Cas9 Technology |
|
Gene Knockout |
|
Conventional (constitutive) gene knockout, Conditional gene knockout, KO first |
|
Gene Knock-in |
|
Conventional gene knock-in, Point mutation, Conditional point mutation, Humanization |
|
Gene Overexpression |
|
Targeted conditional overexpression, Random Transgenes |
|
|
| |
|
Applications of Animal Models |
|
Study of gene functions |
|
To study the in vivo function of a gene or its encoded protein and identify its role within cellular processes. |
|
Research on human diseases |
|
To mimic human diseases for the research on pathogenesis, development processes, gene-regulation, therapeutic treatments, etc. Cancer, Hemophilia, Dysgenesis, Inflammation, Aging and Longevity, Osteoporosis, Pleomorphic Adenoma |
|
Drug screening |
|
To allow focused and high-throughput in vivo drug screening for more valuable pre-clinical research and accelerate drug development. |
|
Gene tracking |
|
To visualize the in vivo expression of genes or proteins to uncover cell fate and genetic lineage. |
|
|
| |
|
| |
|
|
 |
| |
|
|
|
| |
| |
|
|
|
|
